Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11) Antibody

ATP-sensitive potassium (K (ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K (ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.

Target	Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNJ11.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14654 (UniProt, ExPASy)
UniProt Secondary AC	B4DWI4, E9PNK0, Q2M1H7, Q58EX3, Q8IW96
UniProt Entry Name	KCJ11_HUMAN
KEGG	hsa:3767
String	9606.ENSP00000345708
Molecular Weight	Calculated MW: 43.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rabbit KCNJ11.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11)

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