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Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11) Antibody
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Catalogue No: abx034279
Price:
US$326.25
(Size: 80 µl)
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ATP-sensitive potassium (K (ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K (ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.
Research Articles on Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11)
| Target | Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNJ11. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q14654 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DWI4, E9PNK0, Q2M1H7, Q58EX3, Q8IW96 |
| UniProt Entry Name | KCJ11_HUMAN |
| KEGG | hsa:3767 |
| String | 9606.ENSP00000345708 |
| Molecular Weight | Calculated MW: 43.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rabbit KCNJ11. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |