Potassium Intermediate Small Conductance Calcium Activated Channel Subfamily N, Member 1 (KCNN1) Antibody

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.

Target	Potassium Intermediate Small Conductance Calcium Activated Channel Subfamily N, Member 1 (KCNN1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human KCNN1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q92952 (UniProt, ExPASy)
UniProt Secondary AC	Q5KR10, Q6DJU4
UniProt Entry Name	KCNN1_HUMAN
KEGG	hsa:3780
String	9606.ENSP00000476519
Molecular Weight	Calculated MW: 60 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Potassium Intermediate Small Conductance Calcium Activated Channel Subfamily N, Member 1 (KCNN1)

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