Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD) Antibody

Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD) Antibody is a Rabbit Polyclonal antibody against Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD). This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Target	Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 75-334 of human LECT1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O75829 (UniProt, ExPASy)
UniProt Secondary AC	Q5TAM4, Q8TAY6, Q9UM18
UniProt Entry Name	CNMD_HUMAN
Gene Symbol	CNMD
GeneID	11061
NCBI Accession	NP_008946.1
KEGG	hsa:11061
String	9606.ENSP00000367198
Molecular Weight	Calculated MW: 37 kDa Observed MW: 37 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD)

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