Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF) Antibody

MANF Antibody is a Rabbit Polyclonal antibody against MANF. The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

Target	Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 25-182 of human ARMET/ARP/MANF.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P55145 (UniProt, ExPASy)
UniProt Secondary AC	Q14CX4, Q86U67, Q96IS4
UniProt Entry Name	MANF_HUMAN
Gene Symbol	MANF
GeneID	7873
NCBI Accession	NP_006001.5
KEGG	hsa:7873
String	9606.ENSP00000432799
Molecular Weight	Calculated MW: 21 kDa Observed MW: 16 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue