MEK Kinase Kinase 4 (MAP4K4) Antibody

A Ser/Thr kinase of the STE20 subfamily. May play a role in the response to environmental stress and cytokines such as TNF alpha. May interact with the SH3 domain of the adapter proteins Nck. Binds, via its CNH regulatory domain, to the N- terminal region of SPG3A. Upregulated in primary tumors and tumor cell lines. Required for anchorage-independent growth and ras-dependent focus formation in multiple cell lines. 5 isoforms of the human protein are produced by alternative splicing.

Target	MEK Kinase Kinase 4 (MAP4K4)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95819 (UniProt, ExPASy)
UniProt Secondary AC	E7ESS2, O75172, Q9NST7
UniProt Entry Name	M4K4_HUMAN
Gene Symbol	MAP4K4
GeneID	9448
OMIM	604666
HGNC	6866
KEGG	hsa:9448
Ensembl	ENSG00000071054
String	9606.ENSP00000343658
Enzyme Commission Number	EC 2.7.11.1
Molecular Weight	142 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on MEK Kinase Kinase 4 (MAP4K4)

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