Macrophage Mannose Receptor 1 (MRC1) Antibody

Macrophage Mannose Receptor 1 (MRC1) Antibody is a Rabbit Polyclonal antibody for the detection of CD206.

CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.

Target	Macrophage Mannose Receptor 1 (MRC1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/200 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	mannose receptor, C type 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P22897 (UniProt, ExPASy)
UniProt Secondary AC	A5PKW3, Q5VSJ2, Q5VSK2
UniProt Entry Name	MRC1_HUMAN
Gene Symbol	MRC1
GeneID	4360
OMIM	153618
HGNC	7228
KEGG	hsa:4360
Ensembl	ENSG00000260314
String	9606.ENSP00000455897
Molecular Weight	Observed MW: 166 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Macrophage Mannose Receptor 1 (MRC1)

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