Protein Inhibitor of Activated STAT3 (PIAS3) Antibody

PIAS3 is a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription) ] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier) E3 ligase stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, catalyzing the covalent attachment of a SUMO protein to specific target substrates. PIAS3 plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.

Target	Protein Inhibitor of Activated STAT3 (PIAS3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 588-619 amino acids of human PIAS3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y6X2 (UniProt, ExPASy)
UniProt Secondary AC	Q9UFI3
UniProt Entry Name	PIAS3_HUMAN
NCBI Accession	NP_006090.2
String	9606.ENSP00000376765
Molecular Weight	Calculated MW: 68 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat PIAS3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Inhibitor of Activated STAT3 (PIAS3)

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