protein Tyrosine Phosphatase 1B (PTP1B) Antibody
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Price:
US$406.00
(Size: 100 µg)
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protein Tyrosine Phosphatase 1B (PTP1B) Antibody is a Rabbit Polyclonal antibody for the detection of PTP1B.
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Target |
protein Tyrosine Phosphatase 1B (PTP1B) |
Clonality |
Polyclonal |
Reactivity |
Human, Rat |
Tested Applications |
ELISA, WB, IHC |
Host |
Rabbit |
Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
protein tyrosine phosphatase, non-receptor type 1 |
Isotype |
IgG |
Form |
Liquid |
Purity |
≥ 95% (SDS-PAGE) |
Purification |
Purified by immunogen affinity chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Validity |
12 months. |
UniProt Primary AC |
P18031 (UniProt,
ExPASy)
|
UniProt Secondary AC |
Q5TGD8, Q9BQV9, Q9NQQ4 |
UniProt Entry Name |
PTN1_HUMAN |
Gene Symbol |
PTPN1 |
GeneID |
5770
|
OMIM |
176885
|
HGNC |
9642
|
KEGG |
hsa:5770
|
Ensembl |
ENSG00000196396 |
String |
9606.ENSP00000360683
|
Molecular Weight |
Observed MW: 50 kDa |
Buffer |
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
Concentration |
2 mg/ml |
Availability |
Shipped within 5-12 working days. |
Note |
This product is for research use only. |
Research Articles on protein Tyrosine Phosphatase 1B (PTP1B)