Proteasome Subunit Alpha Type 5 (PSMA5) Antibody

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PMA5 is a member of the peptidase T1A family, that is a 20S core alpha subunit.

Target	Proteasome Subunit Alpha Type 5 (PSMA5)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 106-135 amino acids from the Central region of human PSMA5.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P28066 (UniProt, ExPASy)
UniProt Secondary AC	B2R8F6, B4E2V4, Q3T1C1, Q6IBF7
UniProt Entry Name	PSA5_HUMAN
KEGG	hsa:5686
String	9606.ENSP00000271308
Molecular Weight	Calculated MW: 26.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow PSMA5.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Proteasome Subunit Alpha Type 5 (PSMA5)

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