Dual Specificity Protein Phosphatase 6 (DUSP6) Antibody

Dual Specificity Protein Phosphatase 6 (DUSP6) Antibody is a Rabbit Polyclonal antibody for the detection of DUSP6. Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of MAP kinases by dephosphorylating critical tyrosine and threonine residues. MKP-3 is 36% identical to MKP-1 and it blocks both the phosphorylation and enzymatic activation of ERK2 by mitogens. MKP-3 mRNA is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis.

Target	Dual Specificity Protein Phosphatase 6 (DUSP6)
Clonality	Polyclonal
Reactivity	Rat
Tested Applications	ELISA, WB, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	6x HIS-tagged recombinant protein encoding 1-381 AA of rat MKP3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q64346 (UniProt, ExPASy)
UniProt Entry Name	DUS6_RAT
NCBI Accession	NP_446335.1
KEGG	rno:116663
String	10116.ENSRNOP00000032969
Molecular Weight	Calculated MW: 42.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dual Specificity Protein Phosphatase 6 (DUSP6)

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