RIC8 Guanine Nucleotide Exchange Factor A (RIC8A) Antibody

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) alpha protein, possibly leading to release G (i) alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) alpha-GDP complex (By similarity). Also acts as an activator for G (q) alpha (GNAQ) protein by enhancing the G (q) coupled receptor-mediated ERK activation.

Target	RIC8 Guanine Nucleotide Exchange Factor A (RIC8A)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 244-272 amino acids from the Central region of human RIC8A.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NPQ8 (UniProt, ExPASy)
UniProt Entry Name	RIC8A_HUMAN
Gene Symbol	RIC8A
String	9606.ENSP00000325941
Molecular Weight	Calculated MW: 59.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey RIC8A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on RIC8 Guanine Nucleotide Exchange Factor A (RIC8A)

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