Ribosomal Protein S6 (RPS6) Antibody

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Target	Ribosomal Protein S6 (RPS6)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 220-249 amino acids from human RPS6.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P62753 (UniProt, ExPASy)
UniProt Secondary AC	P08227, P10660, Q4VBY7, Q8N6Z7
UniProt Entry Name	RS6_HUMAN
Gene Symbol	RPS6
GeneID	6194
OMIM	180460
HGNC	10429
KEGG	hsa:6194
Ensembl	ENSG00000137154
String	9606.ENSP00000369757
Molecular Weight	Calculated MW: 28.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow, Chicken, Monkey and Xenopus RPS6.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ribosomal Protein S6 (RPS6)

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