Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Antibody

RRM1 Antibody is a Rabbit Polyclonal antibody against RRM1. This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

Target	Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 593-792 of human RRM1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P23921 (UniProt, ExPASy)
UniProt Secondary AC	Q9UNN2
UniProt Entry Name	RIR1_HUMAN
Gene Symbol	RRM1
GeneID	6240
NCBI Accession	NP_001024.1
KEGG	hsa:6240
String	9606.ENSP00000300738
Molecular Weight	Calculated MW: 90 kDa Observed MW: 90 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1)

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