Serpin Family E Member 1 (SERPINE1) Antibody

SERPINE1 Antibody is a Rabbit Polyclonal antibody against SERPINE1. This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Serpin Family E Member 1 (SERPINE1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/100 - 1/500, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 24-199 of human PAI-1/Serpin E1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05121 (UniProt, ExPASy)
UniProt Secondary AC	B7Z4S0, F8WD53
UniProt Entry Name	PAI1_HUMAN
Gene Symbol	SERPINE1
GeneID	5054
NCBI Accession	NP_000593.1
KEGG	hsa:5054
String	9606.ENSP00000223095
Molecular Weight	Calculated MW: 45 kDa Observed MW: 48 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	2.11 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Serpin Family E Member 1 (SERPINE1)

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