Splicing Factor 3b Subunit 1 (SF3B1) Antibody

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].

Target	Splicing Factor 3b Subunit 1 (SF3B1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 374-402 amino acids from the N-terminal region of human SF3B1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O75533 (UniProt, ExPASy)
UniProt Secondary AC	E9PCH3
UniProt Entry Name	SF3B1_HUMAN
Gene Symbol	SF3B1
KEGG	hsa:23451
String	9606.ENSP00000335321
Molecular Weight	Calculated MW: 146 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Xenopus SF3B1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Splicing Factor 3b Subunit 1 (SF3B1)

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