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Splicing Factor 3B Subunit 2 (SF3B2) Antibody
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Catalogue No: abx004507
Price:
US$203.00
(Size: 20 µl)
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SF3B2 Antibody is a Rabbit Polyclonal antibody against SF3B2. This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.
Research Articles on Splicing Factor 3B Subunit 2 (SF3B2)
| Target | Splicing Factor 3B Subunit 2 (SF3B2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 616-895 of human SF3B2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13435 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K485, B4DT19, Q7L4T5, Q7Z627, Q969K1, Q96CM6, Q9BWD2 |
| UniProt Entry Name | SF3B2_HUMAN |
| Gene Symbol | SF3B2 |
| GeneID | 10992 |
| NCBI Accession | NP_006833.2 |
| KEGG | hsa:10992 |
| String | 9606.ENSP00000318861 |
| Molecular Weight | Calculated MW: 100 kDa Observed MW: 140 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |