Sox2 (pS249) Antibody

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Target	Sox2 (pS249)
Clonality	Polyclonal
Target Modification	Ser249
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S249 of human Sox2.
Isotype	IgG
Form	Liquid
Purification	Purified by protein A affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with peptides. The antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48431 (UniProt, ExPASy)
UniProt Secondary AC	Q14537
UniProt Entry Name	SOX2_HUMAN
KEGG	hsa:6657
String	9606.ENSP00000323588
Molecular Weight	Calculated MW: 34.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Sheep SOX2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Sox2 (pS249)

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