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Spleen Associated Tyrosine Kinase (SYK) Antibody
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Catalogue No: abx011584
Price:
US$420.50
(Size: 100 µl)
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Syk is a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLC gamma 2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described.
Research Articles on Spleen Associated Tyrosine Kinase (SYK)
| Target | Spleen Associated Tyrosine Kinase (SYK) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of SYK (aa296-484) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P43405 (UniProt, ExPASy) |
| UniProt Entry Name | KSYK_HUMAN |
| Gene Symbol | SYK |
| GeneID | 6580 |
| OMIM | 600085 |
| HGNC | 11491 |
| KEGG | hsa:6850 |
| Ensembl | ENSG00000165025 |
| String | 9606.ENSP00000364907 |
| Enzyme Commission Number | EC 2.7.10.2 |
| Molecular Weight | 72 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |