Synuclein Beta (SNCb) Antibody

Synuclein Beta (SNCb) Antibody is a Rabbit Polyclonal antibody for the detection of SYUB.

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA) -stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Target	Synuclein Beta (SNCb)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	synuclein, beta
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q16143 (UniProt, ExPASy)
UniProt Secondary AC	Q6IAX7
UniProt Entry Name	SYUB_HUMAN
Gene Symbol	SNCB
GeneID	6620
OMIM	602569
HGNC	11140
KEGG	hsa:6620
Ensembl	ENSG00000074317
String	9606.ENSP00000308057
Molecular Weight	Observed MW: 14-18 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Synuclein Beta (SNCb)

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