E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

Target	E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q86TM6 (UniProt, ExPASy)
UniProt Secondary AC	Q8N3K3, Q8N6E8, Q96JL5, Q96PK3
UniProt Entry Name	SYVN1_HUMAN
NCBI Accession	NP_115807.1 NP_757385.1
KEGG	hsa:84447
String	9606.ENSP00000366395
Molecular Weight	Calculated MW: 67.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Xenopus SYVN1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1)

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