E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

SYVN1 Antibody is a Rabbit Polyclonal antibody against SYVN1. HRD1is also named as SYVN1(Synovial apoptosis inhibitor 1), KIAA1810. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Two distinct binding sites mediate Hrd1 dimerization or oligomerization, one located within the transmembrane region and another within the cytosolic domain. (PMID:19864457).Western blot analysis detected abundant HRD1 expression in liver and kidney. Mouse liver and spleen expressed Hrd1 as an 85-kD protein(PMID:12646171).This antibody is specific to HRD1.

Target	E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SYVN1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q86TM6 (UniProt, ExPASy)
UniProt Secondary AC	Q8N3K3, Q8N6E8, Q96JL5, Q96PK3
UniProt Entry Name	SYVN1_HUMAN
Gene Symbol	SYVN1
GeneID	84447
NCBI Accession	NP_757385.1
KEGG	hsa:84447
String	9606.ENSP00000366395
Molecular Weight	Calculated MW: 68 kDa Observed MW: 68 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1)

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