Polyubiquitin-B (UBB) Antibody

This gene encodes ubiquitin, one of the most conserved proteins known.Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover.Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation.Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression.This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence.Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat.Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.

Target	Polyubiquitin-B (UBB)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human UBB expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P0CG47 (UniProt, ExPASy)
Gene Symbol	UBB
GeneID	7314
OMIM	191339
NCBI Accession	BAC56955.1
HGNC	12463
KEGG	hsa:7314
Ensembl	ENSG00000170315
String	9606.ENSP00000304697
Molecular Weight	26 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Polyubiquitin-B (UBB)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue