Ubiquitin Specific Peptidase 8 (USP8) Antibody

USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structur/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.

Target	Ubiquitin Specific Peptidase 8 (USP8)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human USP8.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P40818 (UniProt, ExPASy)
UniProt Secondary AC	B4DKA8, Q2TB31, Q7Z3U2, Q86VA0, Q8IWI7
UniProt Entry Name	UBP8_HUMAN
KEGG	hsa:9101
String	9606.ENSP00000379721
Molecular Weight	Calculated MW: 128 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse USP8.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ubiquitin Specific Peptidase 8 (USP8)

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